THC-Celecoxib Combo for Alzheimer's

Scientists led by Dr. Zhu Youzhen at the University of Texas Health Science Center at San Antonio have discovered that a combination of low-dose Tetrahydrocannabinol (THC) and the anti-inflammatory drug celecoxib can protect memory and reduce brain damage associated with Alzheimer s disease in mice. The research addresses Tetrahydrocannabinol's known side effect of increasing COX-2, an enzyme linked to inflammation and memory impairment. By combining Tetrahydrocannabinol with celecoxib, a COX-2 inhibitor, the team achieved improved learning and memory, reduced beta-amyloid plaques and tau tangles, and lowered brain inflammation. The fact that both Tetrahydrocannabinol (in synthetic forms) and celecoxib are already approved by the United States===Food and Drug Administration could significantly expedite human trials, offering a promising new strategy for the millions affected by Alzheimer s disease.